{"id":617,"date":"2018-04-12T11:31:20","date_gmt":"2018-04-12T09:31:20","guid":{"rendered":"https:\/\/britishdailynews.co.uk\/?p=617"},"modified":"2018-04-06T11:32:30","modified_gmt":"2018-04-06T09:32:30","slug":"humans-produce-new-brain-cells-throughout-their-lives-say-researchers","status":"publish","type":"post","link":"https:\/\/britishdailynews.co.uk\/?p=617","title":{"rendered":"Humans produce new brain cells throughout their lives, say researchers"},"content":{"rendered":"<p>Humans continue to produce new neurons in a part of their brain involved in learning, memory and emotion throughout adulthood, scientists have revealed, countering previous theories that production stopped after adolescence. The findings could help in developing treatments for neurological conditions such as dementia.<\/p>\n<p>Many new neurons are produced in the hippocampus in babies, but it has been a matter of hot debate whether this continues into adulthood \u2013 and if so, whether this rate drops with age as seen in mice and nonhuman primates.<\/p>\n<p>Although some research had found new neurons in the hippocampus of older humans, a recent\u00a0<a class=\"u-underline\" href=\"https:\/\/www.nature.com\/articles\/nature25975\" data-link-name=\"in body link\">study<\/a>\u00a0scotched the idea, claiming that new neurons in the hippocampus were at undetectable levels by our late teens.<\/p>\n<p>Now another group of scientists have published research that pushes back, revealing the new neurons are produced in this brain region in human adults and does not drop off with age. The findings, they say, could help in the hunt for ways to treat conditions ranging from Alzheimer\u2019s to psychiatric problems.<\/p>\n<p>\u201cThe exciting part is that the neurons are there throughout a lifetime,\u201d said Dr Maura Boldrini from Columbia University in New York and first author of the new study published in the\u00a0<a class=\"u-underline\" href=\"http:\/\/www.cell.com\/cell-stem-cell\/fulltext\/S1934-5909(18)30121-8\" data-link-name=\"in body link\">journal Cell Stem Cell<\/a>. \u201cIt seems that indeed humans are different from mice \u2013 where [neuron production] goes down with age really fast \u2013 and this could mean that we need these neurons for our complex learning abilities and cognitive behavioural responses to emotions,\u201d she said.<\/p>\n<p>Boldrini and colleagues looked at the hippocampus in 28 men and women aged between 14 and 79, collected just hours after they had died. Importantly, Boldrini notes, all of the individuals were healthy before death, unlike in many previous studies.<\/p>\n<p>Using a number of techniques, the team examined the degree of new blood vessel formation, the volume, and the number of cells of different stages of maturity, in an area known as the dentate gyrus \u2013 the region of the hippocampus where new neurons are produced.<\/p>\n<aside class=\"element element-rich-link element--thumbnail element-rich-link--upgraded\" data-component=\"rich-link\" data-link-name=\"rich-link-1 | 1\">\n<div class=\"rich-link tone-news--item rich-link--pillar-news\">\n<div class=\"rich-link__container\">\n<div class=\"rich-link__read-more\">\n<div class=\"rich-link__read-more-text\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/aside>\n<p>\u201cAccording to mice studies there are these pluripotent stem cells that are a pool of cells that don\u2019t normally do anything, they are quiescent, and then they can undergo division,\u201d said Boldrini, adding that some studies have suggested that we might be born with a finite pool of these \u2018mother cells\u2019. \u201cThose daughter cells are the ones that exponentially divide and make many more cells and differentiate towards becoming a neuron.\u201d<\/p>\n<p>The team found levels of these \u201cmother cells\u201d dropped with age in the front and middle region of the dentate gyrus. However, levels of the cells they give rise to did not drop, with the team finding thousands of new, immature neurons in the dentate gyrus at the time of death regardless of age.<\/p>\n<p>\u201cWe can still make enough neurons even with fewer left of these \u2018mothers\u2019.\u201d said Boldrini.<\/p>\n<p>However, there was a drop in the front of the dentate gyrus in the number of cells producing substances linked to neuroplasticity \u2013 the ability for the brain to change or \u201crewire\u201d.<\/p>\n<p>\u201cEven though we make these new neurons, they might be less plastic, or maybe making fewer connections or migrating less,\u201d said Boldrini.<\/p>\n<p>The authors note that a drop in plasticity might help explain why even healthy people can become more emotionally vulnerable as they age, but that the formation of new cells including neurons might help protect against cognitive or emotional decline.<\/p>\n<p>Boldrini said it was now important to look at what happens in the brains of those with Alzheimer\u2019s and emotional problems, since if there are differences in the formation of new cells in the hippocampus it could offer scientists new targets for treatment.<\/p>\n<aside class=\"element element-rich-link element-rich-link--tag element--thumbnail element-rich-link--upgraded\" data-component=\"rich-link-tag\" data-link-name=\"rich-link-tag\">\n<div class=\"rich-link tone-news--item rich-link--pillar-news\">\n<div class=\"rich-link__container\">\n<div class=\"rich-link__read-more\">\n<div class=\"rich-link__read-more-text\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/aside>\n<p>Dr Mercedes Paredes from the University of California San Francisco, an author of last month\u2019s paper suggesting adults do not develop new neurons, said she was not persuaded. \u201cFor now, we do not think this new study challenges what we have concluded from our own recently published observations: if neurogenesis continues in the adult human hippocampus, it is an extremely rare phenomenon,\u201d she said. \u201cIt boils down to interpretation of equivocal cells which we took extra steps to characterise extensively and showed not to be new neurons as they first appeared.\u201d<\/p>\n<p>But Dr Niels Haan from Cardiff University said he was convinced new neurons form in the adult human brain, although their function was as yet unclear.<\/p>\n<p>\u201cWe know from work in animal models that adult born neurons are required for various learning and memory processes, and there is some evidence suggesting neurogenesis is disrupted in human psychiatric conditions,\u201d he said. \u201cThis is a promising area for potential treatments.\u201d<\/p>\n<p>Source\u00a0https:\/\/www.theguardian.com\/science\/2018\/apr\/05\/humans-produce-new-brain-cells-throughout-their-lives-say-researchers<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Humans continue to produce new neurons in a part of their brain involved in learning, memory and emotion throughout adulthood, scientists have revealed, countering previous theories that production stopped after adolescence. The findings could help in developing treatments for neurological conditions such as dementia. Many new neurons are produced in the hippocampus in babies, but [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":619,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[11],"tags":[],"_links":{"self":[{"href":"https:\/\/britishdailynews.co.uk\/index.php?rest_route=\/wp\/v2\/posts\/617"}],"collection":[{"href":"https:\/\/britishdailynews.co.uk\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/britishdailynews.co.uk\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/britishdailynews.co.uk\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/britishdailynews.co.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=617"}],"version-history":[{"count":1,"href":"https:\/\/britishdailynews.co.uk\/index.php?rest_route=\/wp\/v2\/posts\/617\/revisions"}],"predecessor-version":[{"id":618,"href":"https:\/\/britishdailynews.co.uk\/index.php?rest_route=\/wp\/v2\/posts\/617\/revisions\/618"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/britishdailynews.co.uk\/index.php?rest_route=\/wp\/v2\/media\/619"}],"wp:attachment":[{"href":"https:\/\/britishdailynews.co.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=617"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/britishdailynews.co.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=617"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/britishdailynews.co.uk\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=617"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}