In the last ten years, in Italy, its incidence has grown at a higher rate than any other type of cancer: in 2006, people with melanoma were little more than 7,000, in 2016 even 13,800. In recent years, however, the life expectancy of those affected by this terrible neoplasia has increased significantly: scientific research has in fact developed a series of immuno-oncological therapies that allow to obtain excellent results even in patients with metastatic disease. To illustrate the importance of this important therapeutic innovation, is prof. Paolo Ascierto, director of the Melanoma Oncology Unit, Oncological Immunotherapy and Innovative Therapies of the National Cancer Institute “G. Pascale “of Naples and president of the Melanoma Foundation.
Prof. Ascierto, is immunotherapy a hope founded?
Absolutely yes. Thanks to the use of particular drugs, it is now possible to act on the body’s immune system to stimulate it to selectively attack cancer cells. The first approved immuno-oncologic molecule, Ipilimumab, showed that 20% of those affected by the metastatic disease are alive 10 years after diagnosis (previously the average survival in the metastatic stage was only 6 months, with a mortality rate at one year of 75%). Further advances have been made thanks to the discovery of two other immuno-oncological molecules: Nivolumab and Pembrolizumab, with 50% of live patients at three years of age. Very important results that confirm the effectiveness of immunophobia in the fight against metastatic melanoma.
What is the state of health of cancer research in Campania?
The Institute ‘Pascale’ of Naples is undoubtedly an important point of reference in the international healthcare scene. Between 2006 and 2016, 1,050 cancer patients were treated with immuno-oncology at Pascale: 500 in daily clinical practice and 550 in trials. This experience, developed with new treatments that stimulate the immune system against the disease, has made the center of Naples one of the most important in the world in the treatment of tumors. Also in Campania, the Società Campana di Immunoterapia Oncologica (SCITO) was recently founded, with the aim of promoting awareness of new therapeutic strategies in the field of oncology, thus giving a significant boost to scientific research. The Melanoma Onlus Foundation, which I have the honor of chairing since 2010, aims, instead, to raise awareness on the importance of early diagnosis. A mission, which in the last 7 years, has enabled us to save many human lives.
For more info (www.fondazionemelanoma.org) (www.scito.it) (www.istitutotumori.na.it)
Quality dental care is a right for everyone. Passion, professionalism and transparency at the service of the patient
Passion, professionalism and transparency: these are the distinctive features of the Dental Ethics clinics, which are demonstrating a new approach to the patient and aspire to be identified as an example of all-Italian dental excellence.
An important reality in the field of dentistry born from the desire of the founder, the dott. Simone Giacomoni, to realize a dream that he cultivated since childhood: give a smile to everyone, with accessible care and certified quality.
A dream born from his personal history, from the teachings of his father Lucio, a doctor and a great professor who has spent his life for the community. Offer the best dental care possible, always putting the person and its peculiarities in the middle: this is the pragmatic philosophy of a Group that has successfully treated more than 50 thousand people throughout Italy.
Strong of cutting-edge technologies and constant professional updating, Etica Dentale is able to offer high quality, safe and complete performances in the different branches of dentistry. A wide range of therapies, strictly tailored to the specific clinical needs of each patient.
With 18 avant-garde clinics, located in Lazio and Lombardy (with the exception of the Pescara office), and thanks to the help of up-to-date and competent doctors, Etica Dentale aims to take care of patients with great attention to the human aspect, combined with the quality of dental services.
Dental Ethics wants to go back to being the “district dentist”, with roadside centres open every day.
Attorney Marino, what services can a tax lawyer offer the citizen?
The tax lawyer, lawyer specialized in the complicated subject of tax law, is the professional figure to which the citizen can address in all cases where you want to have a legal advice on tax and tax, in order to better understand the complicated legislation of the sector, and to defend against the Revenue in case the claims made by the latter are actually erroneous and unfounded. It should not be forgotten that the Public Administration (which also includes tax agencies, and in particular the Revenue Agency, as well as local authorities, such as municipalities, provinces and regions) is still composed of people who , as such, they can make mistakes. Think of the recent scandal of Ta.ri. – the Tax on Waste – illegally requested in excess by many municipalities on boxes, cellars, attics, etc., or the famous affair of the c.d. “Crazy folders”.
Coming to the activity carried out by its law firm, what are the main areas of expertise?
My office – based in Rome – has been dealing with tax and tax consultancy for years, both judicial and extrajudicial. We are specialized in the defense of the tax payer at 360 degrees on all issues related to taxes and various taxes, both before the Tax Commissions and – in the last instance – before the Court of Cassation. The firm also assists the client in direct relations with the offices of the financial administration.
The evolution of the family concept and the anachronism of family legislation
In Italy the traditional family is no longer the only one; the reality of human and social relationships, also for the interaction with other cultures, has generated various forms of experiences, with the reduction of religious marriages and the increase of separations, of children born out of wedlock, of stable ties without conjugal relations , of unveiling of homosexual unions. The law has introduced new institutions (civil unions, cohabitation contracts, legal equality of all children, protection against domestic violence) and, as claimed by lawyer. Alfredo Guarino, “respecting the principles, family law must offer instruments that are suitable for the concrete needs of every citizen”.
The introduction of premarital agreements is desired by many. Why?
In this way (in France the spouses can choose between four asset regimes), it would be possible to regulate relations in advance, even by separation or divorce, avoiding laboriously trying to settle disputes when the marriage went into crisis and the the weight of recriminations hinders the definition of satisfactory solutions, accentuating conflict. An ad hoc law is therefore awaited.
A recent judgment of the Court of Cassation changed the calculation of the divorce allowance. Do you agree?
It seems preferable to relate the allowance to the period of effective cohabitation and to the real contribution to family life. Equally it should be for the severance pay, today devolved in the sole hypothesis of divorce in the fixed quota of 40%, equating dissimilar cases and considering the years in which the employment relationship coincided with the marriage. The calculation is thus completed including the whole phase of separation, since the marriage remains until the divorce is pronounced. In my opinion it is an unfair rule, which penalizes spouses who have obtained only personal separation (consensual or judicial), who are excluded and sometimes do not require divorce for religious convictions.
Does the modernization of family law require an adequately prepared lawyer?
The new challenges of the legal profession require lawyers with serious legal preparation and ability to listen to the needs of their clients. Moreover, faced with the intensification of family crises, which often result in criminal conduct, it is necessary to be able to graduate the instruments of civil and penal protection law; finally, international unions and transfers of residence abroad require knowledge of the legal consequences that may derive from family law and succession (sometimes with dramatic consequences for relations with minor children and for the loss of legitimate shares). in heredity).
For more info (www.alfredoguarinoavvocato.com) (alf.guar.leg.off@libero.it)
AGMJewels, a limited liability company in 2010 and owned by the Bonacci family, boasts many years of experience in the trade of precious and related objects, which has committed them to become a point of reference not only for the city of Pignataro Maggiore, already known an international level for its goldsmith production, but also for all the main surrounding metropolitan areas. The mission of this company is, in fact, to widen its horizons beyond the regional boundaries, it is the leadership in the supranational trade of jewels and similar. After 4 generations, today is Gennaro Bonacci to lead the business, strong of a long family tradition, handed down with passion from father to son since 1910.
Dr. Bonacci, what are the hallmarks of the company?
Profound knowledge of the market of goods, security, trust and reliability, are the distinctive features of AGMJewels , which has always been at the service of its customers with experience and professionalism. It is no coincidence that this all-Italian brand is universally recognized as a synonym of reliability and guarantee of excellent service. Thanks to the adoption of winning company policy practices, to its ability to renew itself repeatedly in relation to the changes in the reference market, to the many years of experience gained in the sector, to the meticulous attention to the evolution of the jewels styles, AGM jewels has managed to be a series of strategies aimed at creating the highest level of customer satisfaction.
What kind of products do you offer to your customers?
Our company offers high quality precious and the most prestigious brands; products ranging from jewelery, goldsmithery, silverware, watchmaking to custom objects / favors, always ensuring excellent assistance. In fact, for some time now my company has focused on successful brands, including: Dogi Gioielli, Oroverde e Figli, Sovrani Argenti, Braccialini, Bulova, Fossili, Cuore Matto, Egan, Laura Biagiotti, Stroili Oro, Nominato, Sagapo and UnoAerre.
Nowadays, to buy a jewel Is it still a good investment?
Today it is a common value is a common desire is usually to stand out, get noticed and admire. What is certain is that the purchase of a brand is an advantage accessory, in a time is an object that is revalued from year to year.
From the prototype on paper to the final product. Luisstyle is the new brand launched in 2012 by a young man, Luigi Aprea, who just graduating in Engineering, decides for a strange case of the fate of launching himself into a new challenge, that of creating models of prescription and sun glasses with unexceptionable design and original, taking care of all stages of the production process.
Dr. Aprea, his story is really incredible, can you tell us about it?
On the day of the dissertation I found a pair of broken glasses on the street. At first I did not pay much attention to the episode. But when in 2009 I was hired by an optical company, I thought inside of me that it was really a strange coincidence. So a few years later I decided to create my own brand.
The rise to success was really quick. What are the strengths of its brand?
The creation of aesthetically beautiful, indestructible and trend-setting accessories is the main reason for the rapid rise to success of our all-Italian brand which, over the last few years, has considerably expanded its authorized retailer fleet, consisting exclusively of optics which continuous technical assistance is provided (also through social channels). The Italian eyewear landscape has thus enriched itself with a young and dynamic company capable of launching on the market products with a cheeky and captivating style, quickly becoming the emblem of Italian fashion. A brand that today aims at internationalization and that during the international optics fair, Mido, which will be held in Milan on 24,25.26 February 2018, will be able to assert its notoriety by presenting the new exciting collection at the Hall n. from the name ETERNAL where the hippie style will be the master.
But his projects do not end here …
Exactly. The Calendar of the Brides is my innovative project that will involve 12 wives (2017-2018-2019), whose irresistible beauty will be immortalized by unique and original artistic shots, which will also highlight the emotions and passions of a woman who is about to take the step more important than his life. The meticulous selection will take place through a casting, which will be accessed only after online registration (www.ilcalendariodellespose.com). The chosen brides, in addition to being the undisputed protagonists of a photographic shoot of author, will benefit from a voucher of 1000 euros to spend during their honeymoon. All 300 participants will have access to a book of discounts and promotions from our partners to be used for their yes day. The project, purely Campania, will involve 12 breathtaking locations, ideal places for exclusive and refined weddings among natural wonders, suggestive settings and enchanting corners of paradise. Among the partners there are 12 ateliers, 12 photographers, 12 hair stylists, 12 make up artists, 6 floral decorators, 6 artisans specialized in wedding favors, 4 furnishing agencies, 4 car rentals, 3 travel agencies, 1 footwear brand and one of eyewear . In short, the Calendar of Brides is really an opportunity to seize on the fly for those who want to help make the wedding atmosphere magical and exciting, even participating in a truly unique project.
For more info (www.luisstyle.com) (info@luisstyle.com) (www.ilcalendariodellespose.com)
Research shows that people can get more work done if they have more screen area available, and using multiple monitors is a simple way to double or triple your workspace. However, that doesn’t mean having three screens is the best option for you or anyone else. The final decision depends on the way you work, the programs you run, the amount of desk space you have available, and how much you are willing to spend.
Some jobs, such as programming and professional video editing, seem to benefit from using multiple screens, and city traders may need more than three screens. Writers might be better off with one big screen, which reduces distractions. In fact, thanks partly to the side-by-side snap feature in Windows, I’ve reverted to using a single screen, and it’s not even that big.
In general, if you need to see a lot of information at once, or at a glance, then it’s better to have multiple screens. The time you would otherwise spend moving or resizing windows is time wasted. If you usually work on one thing at once, then you can Alt-Tab to switch between windows on a single screen.
Switching between three or four virtual desktops is another option.
Travel
According to your email signature, you work for a travel agent. I’m not familiar with TA workflows, but I imagine you need to be logged on to at least one booking system, that you need extra screen area for web research, and that you also have to track incoming emails and messages. It does sound as though three screens would make you more productive. However, the best people to tell you are other travel agents. Try asking many screens they use, and why.
In the UK, staff in most high-street travel agents seem to have a single screen, and usually it’s a small one. I assume this is because they prioritise face-to-face contact with customers. Three big screens would form an impenetrable barrier. In this case, the best solution might be to add a large screen at the side, on an L-shaped desk.
If you don’t work in a customer-facing situation, two or three identical screens might be better.
Either way, multiple screens have been around long enough for people doing different jobs to have evolved their own best practices, and large companies may provide multiple screens as standard for roles where they are most effective. Evolution continues as some people try new approaches while others get hired by different companies and take their established preferences with them.
Decent 24in monitors are widely available for £100 to £200, so cost is hardly a barrier. The gains in productivity (PDF) more than cover the costs.
Screen area matters
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In the old days – 20 years ago – flat screens were small and expensive. When Apple introduced its first 15in Studio Display, it had a maximum resolution of 1024 x 768 pixels and cost $1,999 (or $3,000 in today’s money). As prices came down, it made sense to use two 12in or 14in flat panels side by side, working as a single monitor. The extra screen area really did make you more productive even if there were a couple of thick bezels right in front of your nose.
One widescreen would have been better, but they weren’t available at the time. Now they are.
Today, there’s less need to use two screens side by side rather than one big screen. You get too much extra width, which necessitates neck movements, and not enough extra depth. A 27in to 30in monitor with a resolution of up to 3840 x 2160 pixels (4K) may well be the equivalent of four older LCDs, or two smaller screens side-by-side.
Either way, there’s no doubt that you can be much more productive on a big screen than a small one. Just use a 24in or 27in monitor for a while then switch to a 10in laptop and you will feel the pain.
Two or three?
Multiple screens come into their own when you have different tasks, or one task with very different aspects. While editing, for example, you could have one screen for controls and another for image displays. Some people might find a second screen useful for keeping half an eye on communications feeds such as emails, Slack, Teams or Twitter, and so on. Other users might want news feeds, share price updates, video streams or whatever.
If you multitask, it makes sense to have two screens side by side, and you can buy suitable mounting brackets. If you have one screen for core work and a second screen for monitoring purposes, have the main screen in front of you and the other at an angle by the side.
If you have the desk space, you can move up to three screens, like Bill Gates and Al Gore. This is certainly attractive if you play flight simulation or racing games, where three screens provide a more immersive wraparound effect, and it would be good for showing holiday destinations.
In my experience, it’s best to buy two or three identical screens for the job. If they are from a good supplier, they will provide near-enough the same brightness, colour rendering and reaction speed (or latency). I’ve tried adding odd “spare” screens but the differences in rendering soon become annoying. YMMV.
Screens or windows?
How big do you like your program windows? Alternatively, are you one of life’s switchers, or are you a resizer?
In the early days of personal computing, screens were small and screen resolutions were low, perhaps 640 x 480 or less. It made sense to run programs full screen. If you used multiple monitors, you would have a different program on each screen, and they would all be running full screen. It was easy to switch your attention between them.
But you probably don’t want to run programs full screen on a 25in or larger monitor with a resolution of 1920 x 1080 to 2560 x 1600 pixels. There are exceptions such as graphic arts, architecture, design and editing programs, and some people have very large spreadsheets. However, most people with big screens end up resizing and moving windows around, with two or more programs often overlapping.
Think about how much screen area you need for your main program(s)? Would having a really big screen allow you to enter data or read timetables without scrolling? That’s a time-saver.
Would you be able to use several programs side by side, perhaps tiled so they fill the whole screen? (This is what Snap Assist does.)
If you want to switch your attention between several programs, does each one need its own screen?
If you’re a switcher, I’d tend to go for two or three smaller screens, perhaps around 20in to 24in, with a different program on each. If you’re a resizer, you might prefer one big 27-30in screen.
To pick the best option, you’ll need to think about the software you use and how you use it. Only then can you decide how many screens would suit you best.
The global smartphone market fell 9% in a year this quarter, the biggest fall in smartphone history, with even Apple’s iPhone sales down 1% as users hang on to their phones longer.
For Apple, which is shipping 5m fewer smartphones than a year ago, the decline is offset by an increase in the average sale price of its iPhone, thanks to the popularity of its £1,000 iPhone X.
But as Samsung and others join Apple in pushing the top end of the market to higher prices the demand for new phones appears to be waning. Data from Strategy Analytics shows global smartphone shipments shrank year-on-year from 438.7m to 400.2m in the fourth quarter of 2017.
Linda Sui, director at Strategy Analytics, said: “It was the biggest annual fall in smartphone history. The shrinkage in global smartphone shipments was caused by a collapse in the huge China market, where demand fell 16% annually due to longer replacement rates, fewer operator subsidies and a general lack of ‘wow models’.”
The iPhone X adopted the market trend of all-screen designs first introduced by the Samsung Galaxy S8 in March. But big leaps in smartphone features, such as ever better cameras, are now behind us, with incremental increases in artificial intelligence now taking the spotlight.
“We’re getting to the point where photo quality is already so good that the focus is turning to the smarts that you build beyond that,” Google’s vice president product manager Mario Queiroz, said last year.
Whether that is enough to excite buyers and drive upgrades remains to be seen.
“Global iPhone volumes have actually declined on an annual basis for five of the past eight quarters,” said Neil Mawston, executive director at Strategy Analytics. “If Apple wants to expand shipment volumes in the future, it will need to launch a new wave of cheaper iPhones and start to push down, not up, the pricing curve.”
Despite the shrinkage in the last quarter the entire market crossed 1.5bn smartphones shipped for the first time in 2017, up 1.3%. But it is a far cry from the year-on-year increase of 158m and 12.3% in 2015 and smaller still than the 48m and 3.3% increase in 2016, as developed nations hit saturation point and first time buyers become upgraders – a much harder sell.
The firm’s latest Alexa-powered addition to its Echo range adds a clock and touchscreen interface to the mix
Amazon’s new Echo Spot is one of the most novel takes on a smart speaker yet, and while it is certainly more than just a smart clock, that’s what it’s best at – an attractive voice-assisted smart desk or bedside-table accessory.
What is it?
The Echo Spot is to the Echo Show what the Echo Dot is to the original Amazon Echo. That is to say, it can do everything the Echo Show can just in a smaller, cheaper ball-shaped device with a circular screen. That includes playing music, answering questions and showing the weather, video from cameras and the like.
The Echo Spot is the first of Amazon’s small army of voice-assistant speakers that can really be considered cute-looking. The 91mm-tall little black or white ball looks incredibly modern with just three buttons on the top and a crisp-looking 2.5in circular screen on the front.
There’s a camera above the screen, a small speaker in the base and a power plug and 3.5mm audio socket in the back. It all looks very neat.
Setup
The Echo Spot runs through a short setup routine on its screen when you plug in the power cable for the first time. After you’ve typed out your wifi password and logged into your Amazon account – which is non-negotiable – you’re greeted with a short video that runs through the basic principles of communicating with the voice assistant Alexa and what the Spot can do.
Most settings are available directly on the screen through a swipe down from the top of the screen, with a few things such as skills and connections to smart home devices handled by the Alexa app on a smartphone or tablet.
What does it do?
Like every other Echo device, the Spot listens out for your choice of wake word – the default is “Alexa” – and then starts streaming what you say to Amazon’s servers, coming back with answers, information or actions on your commands. It’s practically instant.
From Flash briefings, timers and answering questions to smart home control and music playback, the Echo Spot does everything the Echo Show can except for playing web videos, such as YouTube.
The Spot will also do video calling to other camera-enabled Echo devices or smartphones with the Alexa app (or audio calling to other Echo devices), which works well despite the small screen. On a desk you tend to get a bit of an up-the-nose shot, however.
The Spot defaults to a clock face, with your choice of digital or analogue options, most of which are attractive. As with the Show there are options to display photos from your image library, and a cycling collection of information cards such as diary dates, the weather and trending news.
There’s a night mode that dims the screen significantly, which is still easy to read from your bed but was dim enough that it didn’t wake me up. An optional do-not-disturb mode can also silence notifications and calls, allowing only timers and alarms
Sound
The Echo Spot sounds pretty good for a small speaker, and better than the Echo Dot. It’s more than loud enough to command from across the room and clearly hear the answers, and it’s perfectly fine for playing the odd spot of music, particularly as a bed-side speaker. But it isn’t a patch on £100 speakers or the audio-only Echo.
Observations
Hitting the mute button on the top puts a red ring around the screen as well as the button lighting up in red to clearly show it is no longer listening
You can disable the camera entirely in the options menu
You can use it as a Bluetooth speaker and also send audio from it to another Bluetooth speaker
There’s a small progress bar that circles the screen when playing audio or video
Video can be maximised to fill the circular screen, zoomed a little or displayed to fit the diameter of the screen
A blue ring around the screen indicates the direction the Spot thinks you’re talking from
Price
The Amazon Echo Spot costs £120 for one, in black or white, or two for £200.
The Echo Spot is an attractive little addition to Amazon’s smart speaker range. It does everything you might want from a smart speaker, while adding a clock, at-a-glance information and an easy-to-use touchscreen interface for accessing additional features.
It sounds pretty good for a small smart speaker, but not when compared to a traditional wireless speaker costing £120, and not a patch on a traditional Echo. It does makes an excellent music control device, with album art, voice and touch screen control when plugged into a hifi though.
Most will use it on a desk or as a bedside clock. If you don’t want to have your phone next to you while you sleep, perhaps the Echo Spot is a good, less sleep-disturbing surrogate alarm clock.
The reunion with Chelsea on Monday will probably prompt some short‑term nostalgia at Watford. The last time they met, after all, represented – at least for an hour – probably the apogee of the club’s Premier League project, and for all the drama of their league season so far it is possible to pick out a single moment within this single match at which they were at their brightest and best and after which life has never quite been the same.
At Stamford Bridge in October Watford led 2-1, missed a ludicrously straightforward chance to lead 3-1 and generally outplayed their hosts for much of the game. They were a team bursting with attacking threat in the early days of Marco Silva’s leadership, a more convincing and certainly more compelling side than those produced in the club’s two preceding top-flight seasons by Quique Sánchez Flores and Walter Mazzarri.
But with hindsight the move in the 54th minute in which they sliced Chelseaapart before Richarlison inexplicably put a header wide from six yards seems like a watershed in their season. Two days later Everton sacked Ronald Koeman, started their courtship of Silva, and the fragile foundations that the Portuguese coach had been building began to crumble.
When they arrived at Stamford Bridge Watford had 15 points from eight games and were fourth in the table; in 16 league matches since then they have picked up 11 points, the division’s 19th-best record.
Already their matches had featured an unusual number of late goals but before Stamford Bridge they had always swung results in Watford’s favour, rescuing points against Liverpool and West Brom and earning wins against Swansea and Arsenal. That day they conceded twice in the last three minutes to turn a game they should have won into one they lost 4-2, and it has turned into a damaging habit: since then they have conceded a last‑minute winner against Everton and they led 1-0 in the 86th minute against Swansea and in the 89th minute against Crystal Palace yet somehow lost on both occasions.
It was the team’s fragility and timidity that prompted the owners to remove Silva last month, his period in charge being not so much Jekyll and Hyde as Jekyll and hide. As the season unravelled, the team noticed nothing different about Silva’s approach but there was certainly something different about its effect.
“It’s very easy at the front end of a season to galvanise a diverse group of players around a central cause,” says Jeremy Snape, a former England cricketer and sports psychologist. “Everyone’s fit and motivated and fresh, and pre-season tours are the perfect time to get that shared mind-set, and all the diverse cultures can own that mission and go and get it. Then you get into the challenge of tough games and setbacks, and that early focus gets burned away, and you’re left with a question as to whether you can focus and re-energise. That’s a critical time. Once the season is in full flow it can be incredibly hard to arrest any decline – and if the team’s leadership is also lacking focus, it might be impossible.”
Injuries have certainly disrupted their campaign but the greatest difference between the effective, attacking side of August and September and the limp, brittle version more recently witnessed is surely psychological. The club hopes that the changes made over the last fortnight, including the appointment of Javi Gracia and the arrival in January of a couple of new players, most notably the former Everton, Milan and Barcelona winger Gerard Deulofeu, will lift the mood.
It has at least demonstrated one unexpected benefit of the club’s rotating cast of managers: in the summer Richarlison decided to join Watford instead of Ajax because they had a Portuguese coach with whom he could communicate; in January Deulofeu chose Hertfordshire over unnamed alternatives because by then they had a Spanish coach with whom he could communicate.
Gracia’s focus so far has been on the team’s defensive organisation, while under him Watford are yet to score a goal. Their rambunctious early-season form seems increasingly distant. “There have been different moments in this team and I’m focused on trying to reach the best level and to keep it until the end,” Gracia says. “I know there’s not much time but we have tried, day by day, to work a lot and try to improve the level of the team. We’ll see at the end of the season what this team’s true potential is.”
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